Brian Lee
Educational Background:
B.S., College of William and Mary, Williamsburg, Virginia
Ph.D., University of Maryland Graduate School, Baltimore, Maryland
Research Scientist, The Scripps Research Institute, La Jolla, California
Research Interests:
Primarily interested in the structural biochemistry of translational regulation through protein-nucleic acid and protein-protein interactions. Our initial studies focus on the activation of gene expression by cytoplasmic polyadenylation binding protein (CPEB), upon phosphorylation by the Aurora kinase, Eg2. Gene expression is regulated through control of transcription, splicing, export, translation, modification, transport and degradation. While transcriptional regulation represents the primary control mechanism of protein synthesis, translational regulation allows for a quicker response to stimulus and the localization of protein synthesis. My research group utilizes biomolecular NMR spectroscopy to study the interactions and structures of proteins and nucleic acids that participate in translational regulation.
Recent Publications :
Brian M. Lee, Bethany A. Buck-Koehntop, Maria A. Martinez-Yamout, H. Jane Dyson and Peter E. Wright "Embryonic neural inducing factor Churchill is not a DNA-binding zinc finger protein: Solution structure reveals a solvent-exposed -sheet and zinc binuclear cluster." Journal of Molecular Biology 371 (5) 1274-1289 (2007).
Raphael Stoll, Brian M. Lee, Erik W. Debler, John H. Laity, Ian A. Wilson, H. Jane Dyson and Peter E. Wright "Structure of the Wilms tumor suppressor Protein zinc finger domain bound to DNA." Journal of Molecular Biology372 (5) 1227-1245 (2007).